Daugulis鈥� Research Highlighted in C&E News and JACS Spotlight
Work Addresses Copper-Catalyzed Ortho Fluorinations
The work of Olafs Daugulis, 兔子先生 associate professor of chemistry,
was a featured research highlight in two chemistry journals, Chemistry & Engineering
News and the Journal of the American Chemical Society (JACS).
The highlights summarized Daugulis鈥� paper, 鈥�,鈥� published online June 12 in JACS. The featured summaries help make the information more accessible to a broader community of researchers and scientists. Co-authors on the paper were chemistry graduate students Thanh Truong and Kristine Klimovica. The research was funded by the National Institutes of Health and The Welch Foundation.
鈥═he procedure described in the paper adds to recent advances in organofluorine chemistry that are making it easier for chemists to synthesize pharmaceuticals, agrochemicals and radiolabeled agents for medical imaging applications.
Featured Research Summaries
Chemical & Engineering News featured the research in its 鈥淪cience & Technology Concentrates鈥� section. The summary is titled 鈥�.鈥�
JACS summarized the paper in the 鈥淪potlights on Recent JACS Publications鈥� section published on the web on July 8. The summary is titled 鈥�.鈥�
Abstract - June 12 Daugulis JACS Article
We have developed a method for direct, copper-catalyzed, auxiliary-assisted fluorination of 尾-sp2 C鈭扝 bonds of benzoic acid derivatives and 纬-sp2 C鈭扝 bonds of 伪,伪-disubstituted benzylamine derivatives. The reaction employs a CuI catalyst, a AgF fluoride source, and DMF, pyridine, or DMPU solvent at moderately elevated temperatures. Selective mono- or difluorination can be achieved by simply changing reaction conditions. The method shows excellent functional group tolerance and provides a straightforward way for the preparation of ortho-fluorinated benzoic acids.